There are countless places to visit in Italy, certainly more than you can fit into one trip.
If you want to start your vacation in Tuscany, fly into the Galileo Galilei International Airport in Pisa, which is 81.7 km (50.8 mi) west from Tuscany. If you’d rather begin vacationing in the Amalfi Coast and Naples, you can fly into the Naples International Airport, which is 74.8 km (46.5 mi) North of the Amalfi Coast. Some prefer to travel to Rome to get to the Amalfi coast because it’s cheaper, so be sure to double check. For Sardinia, it’s a bit harder to get to as it is the most isolated island in the Mediterranean. You would have take a connecting flight to one of the following airports: Cagliari-Elmas Airport (CAG), Alghero-Fertilia Airport (AHO), or Olbia Airport (OLB) then take a ferry to the island. For Sicily, you can choose to fly into one of the three airports: Palermo Falcone-Borsellino Airport at Punta Raisi 31km (19 miles) west of the city, Trapani Vincenzo Florio Airport at Birgi 15km (9 miles) from Trapani and Catania, Vincenzo Bellini Airport at Fontanarossa 7km (4 1/2 miles) from the city center. Then, you have the option to take a ferry, bus, car, or train to the island.
Once you get to Italy, there are several readily available transportation options for each starting point you choose. Extensive metropolitane (metros) exist in Rome, Milan, Naples and Turin, with smaller metros in Genoa and Catania.
Cities and towns of any size have an efficient urbano (urban) and extraurbano (suburban) bus system. Services are generally limited on Sundays and holidays.
For island starting points like Sicily, the Amalfi Coast, and Sardinia, the best way to get around is by boat, car, or on foot.